Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions
نویسندگان
چکیده
منابع مشابه
Esterases Reacting with Organophosphorus Compounds
The sixty-seven papers in this book are grouped under the following chapters: Esterase Structures, Catalytic Properties of Cholinesterases, Catalytic Properties of Paraoxonases and Related Esterases, Biology of Cholinesterases, Biology of Paraoxonases and Related Esterases, Toxicity and Degradation of Organophosphorus Compounds, Neuropathy Target Esterase, and Miscellaneous. The chapters are pr...
متن کاملThe inhibition of hydrolytic enzymes by organophosphorus compounds.
It has been shown that several hydrolytic enzymes with different specificities undergo similar reactions with diisopropyl phosphorofluoridate (1) and other related toxic organophosphorus compounds (2). These conclusions were based on kinetic studies, particularly the influence of pH on the rates of reaction, and on inhibition characteristics. Reactions of this type have provided a unique method...
متن کاملReaction of Trivalent Organophosphorus Compounds with Selenium
Over the years, evidence has been accumulating [1, 2] that selenium is an essential nutrient in animals, preventing various serious deficiency diseases. On the other hand, no such firm proof for the need of selenium in human nutrition has been established, although several instances of beneficial effects as a result of selenium supplementation of human diet have been reported [3-5]. Although va...
متن کاملProtein adducts as biomarkers of exposure to organophosphorus compounds.
Exposure to organophosphorus (OP) compounds can lead to serious neurological damage or death. Following bioactivation by the liver cytochromes P450, the OP metabolites produced are potent inhibitors of serine active-site enzymes including esterases, proteases and lipases. OPs may form adducts on other cellular proteins. Blood cholinesterases (ChEs) have long served as biomarkers of OP exposure ...
متن کاملAntioxidants in organophosphorus compounds poisoning.
Oxidative stress has recently been implicated as a factor in the mortality and morbidity induced by organophosphorus (OP) compound poisoning. An overwhelming number of research papers are based on studying at the cellular and organ level. Such studies have concluded that antioxidants can be used as an adjunct compound in the treatment of both chronic as well as acute OP poisoning. Still, the ro...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22041761